块体理论在坚硬特厚煤层综放开采中的应用探索

坚硬特厚煤层采用综放开采时,顶煤受到节理裂隙面的截割,将形成相互耦合的块体,当顶煤下方形成临空面时,部分顶煤块体将首先出现垮落。针对此情况,结合现场钻孔窥视运用块体理论研究方法,分析顶煤体受到的截割状况。从块体沿着单一节理面的垮落和双节理面的垮落类型出发,分析其运动关系和动力关系,得到块体滑动垮落与节理面内摩擦角,及其与滑动垮落方向的关系式,为坚硬特厚煤层顶煤垮落分析提供新的研究角度。     

企业全面预算管理与成本管理实务探究 ——以XY化学工业有限公司为例

企业管理过程中,全面预算管理与成本管理相互促进、相辅相成。针对成本管理及全面预算管理的现状及存在的问题,以陕西某化学工业有限公司(XY公司)为案例,开展了优化成本管理及全面预算管理的对策探讨。首先介绍了全面预算管理和成本管理的基本理论及两者的关系,并针对公司现状及存在的问题,提出了优化全面预算管理和成本管控的思路和措施。通过两种管理相结合的方式,形成科学、健全的管理模式,使企业在市场竞争中获得有利地位,实现企业发展的良性循环。     

BiOI/ZIF-8复合材料的制备及光催化性能

利用低温液相沉淀法制备BiOI/ZIF-8复合光催化剂,同时研究ZIF-8复合量对催化活性和反应动力学的影响,采用X射线衍射(XRD)、高分辨透射电镜(HRTEM)、紫外-可见漫反射(UV-Vis DRS)等研究手段对样品进行表征.通过在可见光下降解甲基橙(MO),对其光催化性能进行评价.结果 表明,BiOI/ZIF-8复合光催化剂具有较好的光催化性能,并且当复合量为3％时复合材料光催化降解性能最好,可见光照射60 min后对质量浓度为40 mg/L的MO溶液的降解率达到99.5％.     

基于双边市场理论的云制造平台定价策略

基于双边市场理论,分析了垄断的云制造平台在收取会员费和交易费模式下的最优定价策略,并利用数值仿真分析了两种收费模式下平台最优利润的差异。结果表明:两种模式下的单边最优定价均与缴费方的自网络外部性系数和免费方的交叉网络外部性系数负相关,与免费方用户数量正相关,双边最优定价受各参数影响方向取决于供需方各参数的相对大小;单边定价对象为用户数量相对较多一方,平台两边用户数量相对平衡时,单边最优定价等于双边最优定价,双边定价时的平台最优利润高于单边定价;最优定价策略由平台内交易次数决定,交易次数较多时双边收取交易费模式更优,交易次数较少时双边收取会员费更优,交易次数临界值取决于平台内网络效应和用户数量。     

低GWP制冷剂在热泵行业的应用分析

随着世界各国对于环境问题的日益关注,热泵行业中的R22制冷剂产品已经开始逐步降低使用,主流制冷剂R134a、R410A等已经被列入受控物质范围,使用更低GWP的制冷剂成为热泵行业可持续发展的重要支撑.针对现有热泵行业的三大主流细分领域高温热泵、普通热泵、低温环境热泵,分别对各个领域的低GWP制冷剂的应用情况进行分析,提出未来中期和长期的可能发生的冷媒替换形势.同时对R290和CO2两种典型的适用于热泵行业的天然制冷剂进行探讨,分析其未来发展趋势.开发适应于我国国情又能在国际竞争中处于优势的全新低GWP制冷剂(包括天然制冷剂)的热泵产品或将成为行业后续发展方向.     

基于拖曳式瞬变电磁法的渠堤工程快速检测技术研究

针对渠堤工程内部隐患巡查线路长、效率低的问题，研发了拖曳式高精度瞬变电磁系统；为了便于拖曳及快速发现异常，采用小回线、大电流的设计方案，通过恒压钳位技术减少了电流关断时间，并设计了跨环削耦线圈用于剔除互感现象；参照航空瞬变电磁的研究方法，采用快速成像算法来实现数据的快速解译；经过测试验证了该系统的适用性，并通过黄河大堤某排污管及南水北调中线某倒虹吸探测实例印证了拖曳式瞬变电磁法的有效性和优势。     

MicroRNA-181a is elevated by 10-hydroxycamptothecin and represses lung carcinoma progression by downregulating FOXP1

Tumor progression is usually characterized by proliferation, migration, and angiogenesis, which is essential for supplying both nutrients and oxygen to the tumor cells. Therefore, targeting angiogenesis has been considered a promising therapeutic strategy for cancer prevention and treatment. In the present study, we demonstrated that in addition to suppressing lung cancer cell proliferation and migration in vitro, 10-hydroxycamptothecin (10-HCPT) is also capable of inhibiting angiogenesis in vivo with a miR-181a-dependent manner. Mechanistically, by upregulating miR-181a, which in turn downregulating FOXP1, 10-HCPT can inhibit the PI3K/Akt/ERK signaling pathwaymediated angiogenesis. Furthermore, reduced levels of miR-181a have been found in both lung cancer cell lines and xenograft with concurrently elevated levels of FOXP1, VEGF, bFGF, and HDGF. Consistent with the findings from the in vitro experiments, miR-181a impairs neovascularization in our xenograft model. In summary, our findings have not only established the anti-oncogenic role of miR-181a in lung cancer angiogenesis but also suggest that 10-HCPT could be a potential therapeutic reagent for lung cancer treatment.     

Identification of a new Hazelnut disease in Liaoning Province: Hazelnut husk brown rot

Hazelnut husk brown rot has been identified as a new disease in Liaoning Province in recent years. The objective of this study as to identify the pathogen. [Method] In this study, a standard sample of hazelnut husk brown rot was collected from Songmudao Base in Dalian City, Liaoning Province. The pathogen was identified by the studies of the morphology, pathogenicity, and analyses of ITS and LSU sequences. The pathogen was isolated and purified, which was confirmed by Koch’s postulates. The symptoms after inoculation were the same as those collected directly from a diseased tree, which showed that it was the pathogenic fungus. The cultural characteristics and conidia and the morphology of the pathogenic fungi were similar to those of Botrytis cinerea’s. The ITS sequences and LSU sequences were compared to the associated strain sequences in GenBank, with 100% identity to Botrytis cinerea (GenBank accession number: MN589848.1) and Botrytis cinerea (GenBank accession number: KU140653.1), respectively. The infection status of the pathogen on the hazelnut husks was also observed. The studies suggested that the pathogen leading to the hazelnut husk brown rot as a new disease in Liaoning Province was Botrytis cinerea.     

超高效液相色谱法快速测定饮料中赤藓红含量

目的：建立一种简便处理样品并准确快速检测赤藓红含量的超高效液相色谱法(UPLC)。方法：色谱柱为ACQUITY UPLC BEH C18(100 mm×2.1 mm，1.7 μm)；采用二极管阵列检测器，检测波长530 nm；柱温40 ℃；流动相为乙腈—0.02 mol/L乙酸铵溶液(乙酸调节pH至6.25)；梯度洗脱：乙腈0 min—5%，2 min—25%，3 min—45%，6 min—70%，6.5 min—5%，8 min—5%；流速0.3 mL/min；进样量5 μL。待测样品加氨水调节pH至7.00，用5%乙腈水溶液溶解，超声提取30 min，过0.20 μm 滤膜后直接上机测定。结果：赤藓红标准曲线相关系数R2＞0.999，加标回收率为92%~109%，相对标准偏差(RSD)＜3.2%，检出限(LOD)为0.01 mg/L，定量限(LOQ)为0.03 mg/L。结论：该法适用于大批饮料中赤藓红含量的准确快速测定。     

超长寿命小型自然循环铅铋快堆堆芯概念设计研究

以提高铅铋快堆的经济性与固有安全性为目标，开展100 MWt超长寿命小型自然循环铅铋快堆SPALLER-100概念设计，在选用PuN-ThN燃料和²⁰⁸Pb-Bi冷却剂的基础上，提出了一种添加固体慢化剂BeO的燃料组件设计方案，开展了堆芯布置研究和控制棒系统设计，分析了堆芯物理特性与稳态自然循环特性。结果表明：在低燃料装载量和小堆芯体积条件下，SPALLER-100堆芯换料周期达32 a，平均卸料燃耗高达210.38 MW·d/kg(HM)，整个寿期内的反应性系数均为负值。稳态运行工况下燃料包壳、芯块最大温度均小于安全限值，反应堆具备一回路自然循环能力和一定流量自动分配能力。